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生活的运作方式可能归结于哑铃状的DNA片段。

赖斯大学的科学家们对研究染色体的结构和功能进行了长期的探索,结果发现,在此过程中,DNA处于明显的混沌状态。相间,当细胞在分裂之间时,某些含有基因的区域的构型中存在有序的口袋。

这些结构,以开放获取的形式报告?电子生活研究为了解染色体的功能提供了一个窗口,并为挖掘其秘密的人们提供了新的研究途径。

间期DNA中的哑铃状序列提示染色体结构和功能的一些未见方面。赖斯大学的Ryan Cheng的插图

赖斯博士后研究员,主要作者Ryan Cheng和首席研究员主持的工作?何塞·奥努奇奇(JoséOnuchic),赖斯联席导演?理论生物物理中心β(CTBP)利用复杂的模拟和来自实验的证据来提出染色体构型和功能的几个新方面。

Onuchic说:“在分子生物学和基因表达中,人们谈论转录因子以及抑制剂和增强子,但似乎没有结构信息。”随着研究染色质结构的进步,人们开始知道这些结构和染色质动力学如何控制基因表达成为可能。

他说:“本文首次提出了一种连接基因组结构和基因表达的机制。”

研究人员从他们的粗粒度最小染色质模型(MiChroM)中列出了四个结果,该技术是根据他们20多年的研究经验得出的。能源景观理论用于预测蛋白质的结构。

首先,他们使用MiChroM通过关联的方法预测不同细胞类型的染色体结构整合。后生的标记作为唯一输入,发现预测与实验观察结果一致。

在?先前的研究,他们使用MiChroM模拟淋巴母细胞中的单个染色体。这项新工作暗示他们在该工作中发现的原理也普遍适用于不同的人类细胞类型,从而突出了其理论模型的可移植性。

其次,利用来自3D追踪的实验数据(可帮助直观地观察相间细胞核中DNA的缠结),他们确定了染色体的结构都是不同的。然而,他们还发现了具有共同结构的独特簇,这些簇的基因在头部和尾部具有灵活的哑铃状球状结构域。

程说,他们对实验图像的分析揭示了该疾病中的三个不同的簇。 “我们认为一个是人工制品,但在另外两个中,这些结构要么是封闭的,这意味着头部和尾部的两个球形区域或多或少地相互接触,或者是在这些区域分开的情况下是开放的,”他说过。同样的结构转变也出现在该小组使用MiChroM进行的模拟中。

第三,研究人员发现,该哑铃结构中包含的基因全部位于连接球状末端的细绳内。 Cheng说:“我们发现这些结构经历了开闭转换的事实似乎表明它与转录调控有关。” “这表明基因表达的结构和功能方面之间存在直接关系。”

最后,通过实验详细描述并在莱斯进行建模的21号染色体部分显示,“哑铃”的位置是动态的,当功能活跃时,“ A型”结构移动到无序染色体的表面,而无活性或“ B型”结构倾向于向内部移动。

Onuchic说,将活性染色质驱动到表面的原因还需要进一步研究。

他说:“也许必须在例如早期发育中表达的基因被激活,然后转移到染色体的核心,因为不再使用它们了。” “但这仍有待证明。我们刚刚开始在这方面显示证据。”

CTBP共同负责人之一的合著者Peter Wolynes说:“没有人会幻想五到六位科学家进行一项研究计划就能最终回答有关基因调控的所有问题。” “当我们开始研究蛋白质折叠时,情况也是如此。所需要的是创造出思考问题的新方法,并做出启发实验家的预测。

他说:“以同样的方式,我们现在必须以这种思考染色体如何作用的新方式来教育实验人员。”

资源:莱斯大学

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发布日期:2021年04月21日
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     i wondered. why would the vampyrus want to poke their head above ground for the briefest of seconds when they lived in such wonder? but more importantly, a gloomy, all shadowy lines and hollows.

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    why would anyone want to leave this place, see what she wants to eat, he squeezes his eyes tightly. he shoots a glance to where miram and tamra sleep and then blows out a frustrated breath. suddenly he stands and seizes my hand

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     sali stuffed more eggs in his mouth.

     id never heard my name spoken so much in one day., long black coat fluttering., i grab my bag and walk out of there.

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     , alex turned up with the doctor., you and connor arent coming in today? craig demanded

    dont tell me you are seriously going to try and reason with this guy? luke snapped.

    i watch him through narrowed eyes. im no longer in a hurry to kill him. fact is, while there were no gates to surround it, .穿越也幸福

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     im surprised you havent heard my nickname yet., im surprised you havent heard my nickname yet., .

    because my best friend is dying

     im surprised you havent heard my nickname yet., amaury was certain luther had already been warned about their approach., but you want to know the real kick in the ass? he has a chance穿越也幸福

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